Microdosing Protocols

Different protocols exist to optimize benefits and minimize tolerance buildup. Below are two commonly used approaches:

1. The Fadiman Protocol (Classic Microdosing Schedule)

Developed by Dr. James Fadiman, this protocol is the most widely used microdosing schedule. It ensures that the benefits are felt while preventing tolerance buildup.

Schedule:

• One microdosing day, two rest days

• Example: Microdose on Monday, rest Tuesday & Wednesday, microdose again on Thursday

• Repeat for 4-6 weeks, followed by a 2-4 week break

Dosage:

• 5-20µg of LSD (most common: 10µg for beginners)

Purpose & Benefits:

• Enhances mood, productivity, and creativity

• Provides long-term benefits without noticeable tolerance buildup

• Ideal for work, personal projects, and mental clarity

Considerations:

• Effects are subtle but accumulate over time

• Keeping a journal helps track patterns and improvements in mood, focus, and energy levels

2. The Stamets Protocol (Stacking LSD with Lion’s Mane and Niacin)

Created by Paul Stamets, this protocol combines LSD, Lion’s Mane mushroom (Hericium erinaceus), and Niacin (Vitamin B3) to stimulate neurogenesis and enhance cognitive function.

Schedule:

• 4 days on, 3 days off (e.g., Monday-Thursday microdose, Friday-Sunday break)

• Repeat for 4-6 weeks, followed by a 2-4 week reset

Stack Components & Dosage:

• LSD: 5-20µg (sub-perceptual dose)

• Lion’s Mane Mushroom: 500-1000mg (promotes nerve growth factor – NGF)

• Niacin (Vitamin B3): 50-200mg (enhances blood flow to the brain, helping distribute the other compounds)

Purpose & Benefits:

• Supports cognitive enhancement, neuroplasticity, and brain regeneration

• Can aid in memory formation and problem-solving

• May benefit those with neurological conditions like Alzheimer’s and PTSD

Considerations:

• Niacin causes a temporary flush (redness, tingling, warmth), which is harmless

• Some prefer to omit niacin if they find the flushing effect uncomfortable

Suggested Microdosing Dosage Range

Microdoses should be sub-perceptual, meaning they should not induce noticeable psychedelic effects.

Dose: 5µg Very subtle; increased focus and energy. 10µg Standard microdose; improved mood, cognition, and creativity. 15µg Stronger effects; slight perceptual enhancement for some. 20µg+May become noticeable, causing mild visual changes or euphoria

How to Find Your Ideal Dose:

• Start with 5-10µg and increase gradually if necessary

• Effects should be subtle but beneficial (enhanced mood, focus, and clarity)

• If perceptual changes occur (colors become more vivid, slight movement in vision), the dose is too high for microdosing

Expected Effects of Microdosing LSD

While individual responses vary, most microdosers report consistent benefits over time.

Common Benefits:

✅ Enhanced mood & emotional well-being (reduced anxiety and depression)
✅ Increased focus, motivation, and productivity
✅ Boosted creativity and problem-solving abilities
✅ Improved mindfulness, self-awareness, and emotional resilience
✅ More social ease and empathy in interactions
✅ Improved physical energy and reduced fatigue

Possible Side Effects:

While most people tolerate microdosing well, some may experience:
⚠️ Mild anxiety or overstimulation (if the dose is too high)
⚠️ Insomnia or restlessness (especially if taken late in the day)
⚠️ Headaches or mild tension (can be mitigated with proper hydration)
⚠️ Increased emotional sensitivity (may bring up suppressed emotions)
⚠️ Slight nausea (rare, but some individuals may experience stomach discomfort)

Contraindications & Who Should Avoid Microdosing LSD

While LSD microdosing is generally safe for healthy individuals, some people should avoid or exercise caution when using it.

Do Not Microdose If You:

❌ Have a history of schizophrenia, psychosis, or bipolar disorder (LSD may worsen symptoms)
❌ Are currently taking SSRIs, MAOIs, or other psychiatric medications (potential interactions with serotonin levels)
❌ Have a diagnosed anxiety disorder (some may experience overstimulation or unease)
❌ Are pregnant or breastfeeding (safety has not been studied)
❌ Have a history of substance abuse issues (LSD is non-addictive but may encourage habitual use)

Proceed with Caution If You:

⚠️ Have heart conditions or high blood pressure (LSD slightly increases heart rate and blood pressure)
⚠️ Experience migraines or cluster headaches (LSD can be helpful for some but triggering for others)
⚠️ Have a low tolerance for stimulants (start with a very low dose)

Best Practices for Microdosing LSD

To maximize the benefits of microdosing and ensure safety, follow these guidelines:

✅ Start Low & Go Slow – Begin with 5-10µg and adjust as needed
✅ Choose the Right Environment – Microdose on days when you can observe the effects
✅ Take Breaks – Avoid daily microdosing to prevent tolerance buildup
✅ Keep a Journal – Track mood, focus, energy, and creativity to monitor changes
✅ Pair with Healthy Practices – Meditation, exercise, and proper nutrition can enhance benefits
✅ Use Laboratory-Tested LSD – Ensure purity and accurate dosing

Final Thoughts

Microdosing LSD can be a powerful tool for cognitive enhancement, emotional well-being, and creativity, but it is not a cure-all. The key to success is mindful usage, intentionality, and integrating insights into daily life.

If you are considering microdosing, approach it with responsibility, awareness, and proper guidance. Always prioritize safety, listen to your body, and adjust your routine based on your unique experience.

Would you like additional insights, such as tips on sourcing, integration techniques, or alternative protocols?