Microdosing Protocols

Different microdosing protocols exist to optimize the benefits of psilocybin while minimizing tolerance buildup. Below are two well-known approaches:

1. The Stamets Protocol (Paul Stamets’ Microdosing Stack)

Renowned mycologist Paul Stamets introduced a stacking protocol that combines psilocybin, Lion’s Mane mushroom, and niacin (Vitamin B3) to promote neurogenesis (growth of new brain cells) and cognitive enhancement.

Schedule:

• 4 days on, 3 days off (e.g., Monday-Thursday microdose, Friday-Sunday break)

• Repeat the cycle for 4-6 weeks, followed by a 2-4 week break to reset tolerance

Stack Components & Dosage:

• Psilocybin: 0.1 – 0.3g dried mushrooms

• Lion’s Mane Mushroom: 500 – 1000mg (stimulates nerve growth factor – NGF)

• Niacin (Vitamin B3): 50 – 200mg (aids delivery of psilocybin and Lion’s Mane to the brain)

Purpose & Benefits:

• Enhances neuroplasticity and cognitive function

• Supports memory, focus, and learning

• Potentially aids in treating neurodegenerative conditions like Alzheimer’s and Parkinson’s

• Promotes creativity and problem-solving

Considerations:

• Niacin causes a temporary flush (redness, warmth, tingling), which is normal and not harmful. Some people prefer to omit niacin if the flush is uncomfortable.

2. The Fadiman Protocol (James Fadiman’s Classic Schedule)

Pioneering psychedelic researcher Dr. James Fadiman developed this widely used microdosing protocol, designed to minimize tolerance and integrate effects into daily life.

Schedule:

• One microdosing day, two rest days (e.g., Monday microdose, Tuesday-Wednesday break, Thursday microdose, etc.)

• Continue for 4-6 weeks, then take a break of 2-4 weeks

Dosage:

• Psilocybin: 0.1 – 0.3g dried mushrooms

Purpose & Benefits:

• Reduces anxiety, depression, and stress

• Enhances creativity, motivation, and emotional balance

• Allows for better self-awareness and mindfulness

• Avoids tolerance buildup

Considerations:

• Effects should be mild and sub-perceptual

• Keep a journal to track effects on mood, productivity, and creativity

Suggested Microdosing Dosage Range

The ideal microdose varies depending on individual sensitivity, body weight, and personal goals. A typical range is:

• Low Microdose: 0.05 – 0.1g (subtle, good for beginners)

• Standard Microdose: 0.1 – 0.3g (most common range)

• High Microdose: 0.3 – 0.5g (closer to threshold doses, slight perceptual changes may occur)

How to Find Your Ideal Dose:

• Start with 0.1g and increase or decrease gradually if needed

• Effects should be subtle but noticeable (e.g., improved mood, focus, creativity)

• If you feel too stimulated or slightly altered, reduce the dose

Expected Effects of Microdosing Psilocybin

Most users report positive effects, but experiences vary based on individual physiology, mindset, and external factors.

Common Benefits:

• Enhanced mood & emotional balance (less anxiety, depression, stress)

• Increased focus & productivity (better attention span, reduced procrastination)

• Boosted creativity & problem-solving (more fluid thinking, inspiration)

• Improved mindfulness & self-awareness (deeper connection to thoughts & emotions)

• Greater empathy & social ease (improved interpersonal relationships)

• Physical benefits (better sleep, reduced migraines, enhanced energy levels)

Possible Side Effects:

While most people tolerate microdosing well, some may experience:

• Headaches (can be mitigated with hydration and magnesium supplements)

• Digestive discomfort (due to mushroom compounds)

• Slight anxiety or overstimulation (if the dose is too high)

• Fatigue or brain fog (more common if microdosing too frequently)

• Increased emotional sensitivity (can lead to introspection or mild discomfort)

Contraindications & Who Should Avoid Microdosing

Microdosing is not suitable for everyone, and certain individuals should proceed with caution or avoid it altogether.

Do Not Microdose If You:

• Have a history of schizophrenia, psychosis, or bipolar disorder (psilocybin can trigger or worsen symptoms)

• Are currently taking SSRIs, MAOIs, or other antidepressants (potential serotonin interactions)

• Have severe anxiety or PTSD (some may find microdosing beneficial, while others may feel overstimulated)

• Are pregnant or breastfeeding (safety has not been studied)

• Have a history of substance abuse issues (can lead to reliance on microdosing for emotional regulation)

Proceed with Caution If You:

• Have a low tolerance for psychedelics (start with very small doses)

• Are highly sensitive to stimulants or caffeine

• Experience heart conditions or high blood pressure (microdosing can cause mild physiological changes)

Best Practices for Microdosing Psilocybin

To maximize benefits and ensure a safe, positive experience, follow these best practices:

✅ Start Low and Go Slow – Begin with 0.1g and adjust based on how you feel
✅ Choose the Right Environment – Microdose on days when you can be present and observe the effects
✅ Keep a Journal – Track your mood, focus, creativity, and social interactions to notice patterns
✅ Take Breaks – Avoid microdosing every day to prevent tolerance buildup
✅ Pair with Healthy Practices – Meditation, exercise, proper nutrition, and therapy can enhance benefits
✅ Use High-Quality, Lab-Tested Mushrooms – Ensure safety and dosage accuracy

Final Thoughts

Microdosing psilocybin can be a powerful tool for enhancing mental clarity, emotional balance, and well-being, but it is not a magic cure. The key to success is mindful usage, self-awareness, and integration of insights into daily life.

If you are considering microdosing, it’s essential to approach it with intention, responsibility, and proper guidance. Always prioritize your safety, listen to your body, and be open to adjusting your approach based on your unique response to the medicine